ANDICAM (A Novel Dual Imaging CAMera) was the first 2-channel instrument built by the ISL, capable of taking simultaneous images at one optical (UBVRI) and one near-infrared (JHK) filter band.  The ANDICAM used the final version of the OSU "Big D" cryogenic optical bench design, and deployed a 1:1 Offner relay, dichroic, and reimaging cameras to image the same field on to an optical CCD and an HgCdTe array.

ANDICAM was first deployed in 1998 at the CTIO Yale 1-m telescope as part of the YALO consortium,  a collaboration between Yale, Lisbon University, and Ohio State to operate the Yale 1-m as a dedicated queue-scheduled telescope for undertaking long-term photometric monitoring programs.  It operated for 4 years with little or no downtime taking nearly 400,000 images on every clear night.  In 2003, ANDICAM moved to the CTIO 1.3m telescope (the former 2MASS South telescope) as part of the SMARTS consortium (Small and Medium Aperture Research Telescope System) to operate CTIO's small and medium telescopes in the same dedicated queue mode as YALO. Overall ANDICAM operated for 21 years until its retirement in 2019 after taking millions of CCD and IR images.  It remains one of the most scientifically productive instruments built by the ISL.